Experimental Zika
vaccines shots given to mice in Chicago were completely protected when exposed to the virus one to two
months later. According to Professor Adrian Hill, “This
is an encouraging first step in Zika vaccine design and pre-clinical
testing. This new mouse model should be useful for comparative
assessments of the large range of vaccine candidates now being
designed."
And U.S. scientists on their part said, they have developed a model of the Zika virus in monkeys, a close proxy for human disease. Researchers at the University of Wisconsin reported onyesterday that they have successfully infected rhesus macaques with an
Asian strain of the Zika virus that is currently circulating in the
Americas. The study, published in the journal Nature Communications,
shows that monkeys - which have immune responses similar to humans - can
be used to study Zika.
In
the study, David O'Connor and colleagues inoculated eight rhesus
macaques - including two pregnant monkeys - with a strain of Zika virus
currently circulating in the Americas.
All
eight animals were infected. Tests showed viral particles in their
blood, saliva, urine and spinal fluid. All animals stayed infected for
at least 21 days, and some remained infected for at least 57 days.
A
second exposure to Zika 10 weeks after the first did not make the
animals sick, suggesting that antibodies developed by the monkeys
protected them against a second case of Zika. This is a promising sign
that humans may similarly be able to develop protective antibodies
against the virus.
Mosquito-borne Zika virus has swept through the Americas and Caribbean linked to thousands of cases of microcephaly, a rare birth
defect, in Brazil, as well as to neurological disorders. On February 1st 2016, the
World Health Organization declared Zika a global health emergency.
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